Файл: Cell and Molecular Biology [High-Yield].pdf

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Third Edition 

Copyright © 2012 Lippincott Williams & Wilkins, a Wolters Kluwer business

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All rights reserved. This book is protected by copyright. No part of this book may be reproduced in any form or by any means,
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The publisher is not responsible (as a matter of product liability, negligence, or otherwise) for any injury resulting from any material
contained herein. This publication contains information relating to general principles of medical care that should not be
construed as specific instructions for individual patients. Manufacturers’ product information and package inserts should be
reviewed for current information, including contraindications, dosages, and precautions.

Printed in the United States of America

First Edition, 1999
Second Edition, 2007

Library of Congress Cataloging-in-Publication Data

Dudek, Ronald W., 1950-

High-yield cell and molecular biology / Ronald W. Dudek.—3rd ed.

p. ; cm. — (High-yield)

Cell and molecular biology
Includes bibliographical references and index.
Summary: “Where will the time needed to teach a molecular biology course be found? I suspect what will happen is that many

of the “traditional” courses will extend their discussion of various topics down to the molecular biology level. This approach will
work, but it will in effect make molecular biology somewhat disjointed. The student will learn some molecular biology in a
Biochemistry course, some in a Microbiology course, and some in a Histology course, etc. The problem this presents for students
reviewing for USMLE Step 1 is that molecular biology information will be scattered among various course notes”—Provided by
publisher.

ISBN 978-1-60913-573-7 (alk. paper)
1. Molecular biology—Outlines, syllabi, etc.

2. Pathology—Outlines, syllabi, etc.

3. Cytology—Outlines, syllabi, etc.

I. Title.

II. Title: Cell and molecular biology.

III. Series: High-yield series.

[DNLM:

1. Molecular Biology—Outlines.

2. Cell Biology—Outlines.

QU 18.2]

QH506.D83 2012
572.8—dc22

2010038481

DISCLAIMER

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This book is dedicated to my good friend Ronald Cicinelli, who is now a retired vice-president of The

Chase Bank. In our 40 years of friendship, I have witnessed his dedication to family and friends. Ron

brings a unique combination of strength and kindness to every personal interaction. I have been hon-

ored to know him for all these years. His life has been and continues to be, a “high-yield” life.

This book is also dedicated to my godson Alec Ronald Walker, born April 28, 2005. Alec joins a

remarkable and loving family of parents Tim and Laura, sister Gabriella, and brother Brandson. Alec

will certainly be given all the guidance necessary for a successful life, which will give me great joy to

witness. My admonishment to my dear godson is to remember: “To whom much is given, much is

expected.”

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Preface

The impact of molecular biology today and in the future cannot be underestimated. Gene therapy
and cloning of sheep are explained and discussed in the daily newspapers.

The clinical and etiological aspects of diseases are now being explained at the molecular biology

level. Drugs are being designed right now by various pharmaceutical companies to impact molec-
ular biological processes in the treatment of disease (cancer, obesity, etc.). Molecular biology will
be increasingly represented on the USMLE Step 1. One of my main concerns in writing this book
was NOT to write a review of basic molecular biology but to write a book that addressed molecular
biology from a clinical perspective that would be useful and necessary for our future physicians. I
was greatly assisted in this matter by two medical students who took an unsolicited interest in
“High Yield Cell and Molecular Biology” third edition because they appreciated the growing im-
portance of molecular biology for the future physician. In this regard, I would like to acknowledge
the significant contribution of Mr. Jonah Cohen, a third–fourth-year student at the Brown Medical
School and published cancer researcher in NF-

B signal transduction, and Mr. Fateh Bazerbachi, a

third-year student at Damascus University School of Medicine (Syria). Jonah Cohen was especially
helpful in limiting the scope of material to hone in on the most clinically relevant issues and elim-
inating some far-reaching material that was included in the second edition. Fateh Bazerbachi was
especially helpful in identifying new information and clarifying some difficult areas to understand.
I found their assistance to be very helpful and it should benefit all my readers.

How will medical schools teach the clinical relevance of molecular biology to our future physi-

cians? Medical school curricula are already filled with needed and relevant “traditional” courses.
Where will the time needed to teach a molecular biology course be found? I suspect what will hap-
pen is that many of the "traditional" courses will extend their discussion of various topics down
to the molecular biology level. This approach will work, but it will in effect make molecular biol-
ogy somewhat disjointed. The student will learn some molecular biology in a biochemistry course,
some in a microbiology course, and some in a histology course, etc. The problem this presents for
students reviewing for USMLE Step 1 is that molecular biology information will be scattered among
various course notes.

The solution: High Yield Cell and Molecular Biology, third edition. In this third edition, I have

consolidated the important clinical issues related to molecular biology that are obvious “grist-
for-the-mill” for USMLE Step 1 questions and included many of the insightful suggestions of my
readers and reviewers. It is my feeling that “High Yield Cell and Molecular Biology” will be of
tremendous benefit to any serious review for USMLE Step 1. Please send your feedback, comments,
and suggestions to me at dudekr@ecu.edu for inclusion into the next edition.

Ronald W. Dudek, PhD

vii

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