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©2002 CRC Press LLC
44.
Schoemaker H, Claustre Y, Fage D, et al.
Neurochemical characteristics of amisulpride, an
atypical dopamine D2/D3 receptor antagonist with
both presynaptic and limbic selectivity. J Pharmacol
Exp Ther 1997;280:83–97
45.
Schotte A, Janssen PF, Gommeren W. et al.
Risperidone compared with new and reference
antipsychotic drugs: in vitro and in vivo receptor
binding. Psychopharmacology 1996;124:57–73
46.
Travis MJ. Clozapine. A review. J Serotonin Res
1997;4:125–44
47.
Kane J, Honigfeld G, Singer J, Meltzer H. Clozapine
for the treatment-resistant schizophrenic: a double
blind comparison with chlorpromazine. Arch Gen
Psychiatry 1988;45:789–96
48.
Claghorn J, Honigfeld G, Abuzzahab FS Sr, et al. The
risks and benefits of clozapine versus chlorpro-
mazine. J Clin Psychopharmacol 1987;7:377–84
49.
Conley RR, Schulz SC, Baker RW, et al. Clozapine
efficacy in schizophrenic nonresponders. Psycho-
pharmacol Bull 1988;24:269–74
50.
Breier A, Buchanan RW, Waltrip RWI, et al. The
effects of clozapine on plasmanorepinephrine:
relationship to clinical efficacy.
Neuropsycho-
pharmacology 1994;10:1–7
51.
Pickar D, Owen RR, Litman RE, et al. Clinical and
biologic response to clozapine in patients with
schizophrenia. Crossover comparison with fluphena-
zine [see comments]. Arch Gen Psychiatry 1992;49:
345–53
52.
Essock SM, Hargreaves WA, Covell NH, Goethe J.
Clozapine’s effectiveness for patients in state
hospitals: results from a randomized trial. Psycho-
pharmacol Bull 1996;32:683–97
53.
Marder SR, Davis JM, Chouinard G. The effects of
risperidone on the five dimensions of schizophrenia
derived by factor analysis: combined results of the
North American trials. J Clin Psychiatry 1997;58:
538–46
54
Song F.
Risperidone in the treatment of
schizophrenia:
a meta-analysis of randomized
controlled trials. J Psychopharmacol 1997;11:65–71
55.
Overall JE, Gorham DR. The Brief Psychiatric
Rating Scale. Psychological Reports 1962;10:799–812
56.
Tollefson GD, Sanger TM. Negative symptoms: a
path analytic approach to a double-blind, placebo-
and haloperidol-controlled clinical trial with
olanzapine. Am J Psychiatry 1997;154:466–74
57.
Dellva MA, Tran P, Tollefson GD, et al. Standard
olanzapine versus placebo and ineffective-dose olan-
zapine in the maintenance treatment of schizo-
phrenia [see comments]. Psychiatric Serv 1997;48:
1571–7
58.
Small JG, Hirsch SR, Arvanitis LA, et al. Quetiapine
in patients with schizophrenia. A high- and low-dose
double-blind comparison with placebo. Seroquel
Study Group.
Arch Gen Psychiatry 1997;54:549–57
59.
Peuskens J, Link CG. A comparison of quetiapine
and chlorpromazine in the treatment of schizo-
phrenia. Acta Psychiatr Scand 1997;96:265–73
60.
Arvanitis LA, Miller BG. Multiple fixed doses of
‘Seroquel’ (quetiapine) in patients with acute
exacerbation of schizophrenia: a comparison with
haloperidol and placebo. The Seroquel Trial 13 Study
Group. Biol Psychiatry 1997;42:233–46
61.
Rak IW, Jone AM, Raniwalla J, et al. Weight changes
in patients treated with seroquel (quetiapine).
Schizophrenia Res 2000;41(special issue):206
62.
Hellewell JSE, Kalali AH, Langham SJ, McKellar J,
Awad AG. Patient satisfaction and acceptability of
long-term treatment with quetiapine. Int J Psychiatry
Clin Pract 1999;3:105–13
63.
Xiberas X, Martinot JL, Mallet L, et al. In vivo
extrastriatal and striatal D2 dopamine receptor
blockade by amisulpride in schizophrenia. J Clin
Psychopharmacol 2001;21:207
64.
Delcker A, Schoon ML, Oczkowski B, Gaertner HJ.
Amisulpride versus haloperidol in treatment of
schizophrenic patients – results of a double-blind
study. Pharmacopsychiatry 1990;23:125–30
65.
Moller HJ, Boyer P, Fleurot O, Rein W. Improvement
of acute exacerbations of schizophrenia with amisul-
pride: a comparison with haloperidol. PROD-ASLP
Study Group.
Psychopharmacology
1997;132:
396–401
66.
Puech A, Fleurot O, Rein W. Amisulpride, and
atypical antipsychotic, in the treatment of acute
episodes of schizophrenia: a dose-ranging study vs.
haloperidol. The Amisulpride Study Group. Acta
Psychiatr Scand 1998;98:65–72
67.
Carriere P,
Bonhomme D,
Lemperiere T.
Amisulpride has a superior benefit/risk profile to
haloperidol in schizophrenia: results of a multi-
centre, double-blind study (the Amisulpride Study
Group). Eur Psychiatry 2000;15:321–9
68.
Coulouvrat C, Dondey-Nouvel L. Safety of amisul-
pride (Solian): a review of 11 clinical studies. Int Clin
Psychopharmacol 1999;14:209–18
69.
Rein W, Coulouvrat C, Dondey-Nouvel L. Safety
profile of amisulpride in short- and long-term use.
Acta Psychiatr Scand 2000;400(Suppl.):23–7
70.
Colonna L, Saleem P, Dondey-Nouvel L, Rein W.
Long-term safety and efficacy of amisulpride in sub-
chronic or chronic schizophrenia. Amisulpride Study
Group. Int Clin Psychopharmacol 2000;15:13–22
71.
Goff DC, Posever T, Herz L, et al. An exploratory
haloperidol-controlled dose-finding study of zipra-
sidone in hospitalized patients with schizophrenia or
schizoaffective disorder. J Clin Psychopharmacol
1998;18:296–304
©2002 CRC Press LLC
72.
Keck P, Jr, Buffenstein A, Ferguson J, et al. Ziprasi-
done 40 and 120 mg/day in the acute exacerbation
of schizophrenia and schizoaffective disorder: a 4-
week placebo-controlled trial. Psychopharmacology
1998;140:173–84
73.
Daniel DG, Zimbroff DL, Potkin SG, et al.
Ziprasidone 80 mg/day and 160 mg/day in the acute
exacerbation of schizophrenia and schizoaffective
disorder: a 6-week placebo-controlled trial. Ziprasi-
done Study Group. Neuropsychopharmacology 1999;
20:491–505
74.
Arato M, O’Connor R, Meltzer H, et al. The
ziprasidone extended use in schizophrenia (ZEUS)
study: a propective, double blind, placebo controlled,
1 year clinical trial. Data on file, Pfizer Pharmaceutical
Group, 1999
75.
Corbett R, Griffiths L, Shipley JE, et al. Iloperidone:
Preclinical profile and early clinical evaluation. CNS
Drug Reviews 1997;3:120–47
76.
Jain KK. An assessment of iloperidone for the
treatment of schizophrenia. Exp Opin Invest Drugs
2000;9:2935–43
77.
Cucchiaro J, Nann-Vernotica E, Lasser R, et al. A
randomised double-blind, multicenter phase II study
of iloperidone versus haloperidole and placebo in
patients with schizophrenia or schizoaffective
disorder. Schizophr Res 2001;49:223
78.
Lawler CP, Prioleau C, Lewis MM, et al. Interactions
of the novel antipsychotic aripiprazole (OPC-
14597) with dopamine and serotonin receptor sub-
types. Neuropsychopharmacology 1999;20:612–27
79.
Petrie JL, Saha AR, Ali MW. Safety and efficacy
profile of aripiprazole, a novel antipsychotic.
Presented at the 37th Annual ACNP Meeting
80.
Carson WH, Ali M, Saha A, et al. A double-blind
placebo controlled trial of aripiprazole and haloperi-
dol. Schizophrenia Res 2001;49(Suppl. 1–2):221–2
81.
Lieberman JA, Saltz BL, Johns CA, et al. The effects
of clozapine on tardive dyskinesia. Br J Psychiatry
1991;158:503–10
82.
Gerlach J, Peacock L. Motor and mental side effects
of clozapine. J Clin Psychiatry 1994;55(Suppl. B):
107–9
83.
Tamminga CA, Thaker GK, Moran M, et al.
Clozapine in tardive dyskinesia: observations for
human and animal model studies. J Clin Psychiatry
1994;55(Suppl B):102–6
84.
Shapleske J, Mickay AP, Mckenna PJ. Successful
treatment of tardive dystonia with clozapine and
clonazepam. Br J Psychiatry 1996;168:516–18
85.
Jibson MD, Tandon R. New atypical antipsychotic
medications. J Psychiatric Res 1998;32:215–28
86.
Meltzer HY. Pharmacologic treatment of negative
symptoms. In Greden JF, Tandon R, eds. Negative
Schizophrenic Symptoms: Pathophysiology and Clinical
Implications.
Washington, DC: American Psychiatric
Press, 1990:215–31
87.
Tandon R, Ribeiro SC, DeQuardo JR, et al.
Covariance of positive and negative symptoms
during neuroleptic treatment in schizophrenia: a
replication. Biol Psychiatry 1993;34:495–7
88.
Hagger C, Buckley P, Kenny JT, et al. Improvement in
cognitive functions and psychiatric symptoms in
treatment refractory schizophrenic patients receiving
clozapine. Biol Psychiatry 1993;34:702–12
89.
Breier A, Buchanan RW, Kirkpatrick B, et al. Effects
of clozapine on positive and negative symptoms in
outpatients with schizophrenia. Am J Psychiatry
1994;151:20–6
90.
Conley R, Gounaris C, Tamminga C. Clozapine
response varies in deficit versus non-deficit schizo-
phrenic subjects. Biol Psychiatry 1994;35:746–7
91.
Kane JM, Safferman AZ, Pollack S, et al. Clozapine,
negative symptoms, and extrapyramidal side effects.
J Clin Psychiatry 1994;55(9, suppl B):74–7
92.
Carpenter WT Jr. Maintainence therapy of persons
with schizophrenia. J Clin Psychiatry 1996;57
(Suppl. 9):10–18
93.
Tollefson GD, Beasley CM Jr, Tran PV, Street JS.
Olanzapine versus haloperidol in the treatment of
schizophrenia and schizoaffective and schizo-
phreniform disorders: results of an international
collaborative trial [see comments]. Am J Psychiatry
1997;154:457–65
94.
Danion JM, Rein W, Fleurot O. Improvement of
schizophrenic patients with primary negative
symptoms treated with amisulpride. Amisulpride
Study Group. Am J Psychiatry 1999;156:610–6
95.
Boyer P, Lecrubier Y, Puech AJ, et al. Treatment of
negative symptoms in schizophrenia with amisul-
pride. Br J Psychiatry 1995;166:68–72
96.
Paillere-Martinot ML, Lecrubier Y, Martinot JL,
Aubin F. Improvement of some schizophrenic deficit
symptoms with low doses of amisulpride. Am J
Psychiatry 1995;152:130–4
97.
Speller JC, Barnes TR, Curson DA, et al. One-year,
low-dose neuroleptic study of in-patients with
chronic schizophrenia characterised by persistent
negative symptoms. Amisulpride v. haloperidol. Br J
Psychiatry 1997;171:564–8
98.
Meltzer HY, Thompson PA, Lee MA, Ranjan R.
Neuropsychologic deficits in schizophrenia: relation
to social function and effect of antipsychotic drug
treatment. Neuropsychopharmacology 1996;14(Suppl
3):27S–33S
99.
Bilder RM.
Neurocognitive impairment in
schizophrenia and how it affects treatment options.
Can J Psychiatry – Revue Can Psychiatrie 1997;42:
255–64
©2002 CRC Press LLC
100. Lee MA, Thompson PA, Meltzer HY. Effects of
clozapine on cognitive function in schizophrenia.
[Review]. J Clin Psychiatry 1994;55(Suppl B):82–7
101. Gallhofer B, Bauer U, Lis S, et al. Cognitive
dysfunction in schizophrenia:comparison of treat-
ment with atypical antipsychotic agents and conven-
tional neuroleptic drugs. Eur Neuropsychopharmacol
1996;6(Suppl. 2):S13–20
102. Green MF, Marshall BD, Jr., Wirshing WC, et al. Does
risperidone improve verbal working memory in
treatment-resistant schizophrenia? Am J Psychiatry
1997;154:799–804
103. McGurk SR, Meltzer HY. The effects of atypical
antipsychotic drugs on cognitive functioning in
schizophrenia. Schizophrenia Res 1998;29:160
104. Sax KW, Strakowski SM, Keck PE Jr. Attentional
improvement following quetiapine fumarate treat-
ment in schizophrenia. Schizophr Res 1998;33:151–5
105. Peretti CS, Danion JM, Kauffmann-Muller F, et al.
Effects of haloperidol and amisulpride on motor and
cognitive skill learning in healthy volunteers.
Psychopharmacology 1997;131:329–38
106. Zarate CAJ, Tohen M, Banov MD, et al. Is clozapine
a mood stabilizer? J Clin Psychiatry 1995;56:108–12
107. Kimmel SE, Calabrese JR, Woyshville MJ, Meltzer
HY.
Clozapine in treatment-refractory mood
disorders [Review]. J Clin Psychiatry 1994;55(Suppl
B):91–3
108. Calabrese JR, Kimmel SE, Woyshville MJ, et al.
Clozapine for treatment-refractory mania. Am J
Psychiatry 1996;156:759–64
109. Meltzer HY, Okayli G. Reduction of suicidility
during clozapine treatment of neuroleptic-resistant
schizophrenia: impact on risk benefit assessment.
Am
J Psychiatry 1995;152:183–90
110. Banov MD, Zarate CAJ, Tohen M, et al. Clozapine
therapy in refractory affective disorders: polarity
predicts response in long term follow up. J Clin
Psychiatry 1994;55:295–300
111. Rothschild AJ. Management of psychotic, treatment
resistant depression. Psychiatr Clin North Am 1996;
19:237–52
112. Tollefson GD, Sanger TM, Lu Y, Thieme ME.
Depressive signs and symptoms in schizophrenia: a
prospective blinded trial of olanzapine and halo-
peridol [published erratum appears in Arch Gen
Psychiatry 1998;55:1052]. Arch Gen Psychiatry
1998;55:250–8
113. Lecrubier Y, Boyer P, Turjanski S, Rein W.
Amisulpride versus imipramine and placebo in
dysthymia and major depression. Amisulpride Study
Group. J Affect Dis 1997;43:95–103
114. Geddes J, Freemantle N, Harrison P, Bebbington P.
Atypical antipsychotics in the treatment of schizo-
phrenia: systematic overview and meta-regression
analysis. [see comments]. Br Med J 2000;321:1371–6
115. Kapur S, Remington G. Atypical antipsychotics.
[letter]. Br Med J 2000;321:1360–1
116. Prior C, Clements J, Rowett M, et al. Atypical
antipsychotics in the treatment of schizophrenia. Br
Med J 2001;322:924
117. Taylor, D. Low dose typical antipsychotics – a brief
evaluation. Psychiatr Bull 2000;24:465–8
118. Arranz MJ, Munro J, Birkett J, et al. Pharmacogenetic
prediction of clozapine response. Lancet 2000;355:
1615–6
©2002 CRC Press LLC
CHAPTER
5
Psychosocial management
It is obvious that the successful management of
schizophrenia requires careful attention to much
more than just pharmacology. All good clinicians
spend a large proportion of their time dealing with
issues that can broadly be described as ‘psycho-
social’. However, because it is very difficult to
distill the relevant psychosocial issues down to a
set of rigorously evaluable interventions, this
important aspect of treatment is under-researched
and relatively unacknowledged. Research into
specific areas of psychosocial management falls
into two main categories: the effectiveness of
individual psychological therapies, and the
optimal organization of mental health services.
Research in both areas suffers from the perennial
methodological difficulties of adequate control
groups and statistical power, and from questions
over the extent to which one can generalize from
small research settings to large-scale clinical
implementation. Nevertheless, psychosocial inter-
ventions have become increasingly prominent
components of health policy
1
.
PSYCHOLOGICAL THERAPIES
Psychoanalytic psychotherapies have largely been
discredited in the management of schizophrenia,
and indeed cast something of a shadow over the
development of more effective approaches to
treatment. However, a number of very promising
new approaches are now emerging.
Cognitive behavioral therapy
Cognitive behavioral therapy (CBT) encompasses
a variety of interventions. At its core is the idea
that if patients can be presented with a credible
‘cognitive’ model of their symptoms, they may
develop more adaptive coping strategies, leading
to reduced distress, improved social function and
possibly even symptom reduction. CBT involves
regular one-to-one contact over a defined time
period between patient and therapist, the latter
often (but not always) a clinical psychologist
(other professionals including community psych-
iatric nurses and psychiatrists are becoming
increasingly involved as trained therapists)
(
Figure 5.1
). The treatment packages emphasize
engagement and insight, and devote considerable
Figure 5.1
Professor Elizabeth Kuipers, one of the pioneers
of cognitive behavioral therapy (CBT) for psychosis,
treating a ‘patient’ [played here by a colleague]
©2002 CRC Press LLC
attention to agreeing a common therapeutic
agenda. Relatively non-specific elements form an
important component of all treatment packages,
including basic information about schizophrenia
and its drug treatment, strategies to manage
associated anxiety and depression, and inter-
ventions to tackle negative symptoms and social
function. More specific strategies to target positive
symptoms include formulating, together with the
patient, alternative, more adaptive explanatory
models for delusions and hallucinations.
There are, however, substantial differences of
detail between published studies, for example
with respect to the duration of the intervention, or
the incorporation of family work. A distinction is
also made between CBT for acute and for chronic
schizophrenia, although results are encouraging in
both contexts (
Figure 5.2
)
2–5
. However, at the
0.
0
–1.5
–1.0
–0.5
–2.0
Change in score
Distress
Conviction Preoccupation
CHANGE IN DELUSIONAL VARIABLES
CBT Control
Figure 5.2
Sixty patients with
chronic schizophrenia were
randomized to nine months of
cognitive behavioral therapy (CBT)
and standard care, or standard care
alone. At 18 months, patients with
delusions who had received CBT
were found to hold these with a
reduced level of conviction, and
were less preoccupied and distressed
by their delusional beliefs. Figure
reproduced with permission from
Kuipers E, Garety P, Fowler D,
et al.
The London-East Anglia randomised
controlled trial of cognitive-
behavioural therapy for psychosis: III.
Follow-up and economic evaluation
at 18 months.
Br J Psychiatry
173:61–8
60
50
40
30
20
10
0
Responders (%)
Admitted stopping
taking medication
Compliant
with medication
No answer
NON-COMPLIANCE: THE PATIENTS' PERSPECTIVE
Figure 5.3
Over half of a group of
615 patients admitted to having
stopped their medication. Figure
reproduced with kind permission
from Hellewell, JSE. Antipsychotic
tolerability: the attitudes and
perceptions of medical professionals,
patients and caregivers towards the
side effects of antipsychotic therapy.
Euro Neuropsychopharmacol
1998;8:S248